Adv Pharmacol Pharm Sci. 2023 Mar 2;2023:9993386. doi: 10.1155/2023/9993386. eCollection 2023.

ABSTRACT

The nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) has shown promising pharmacological activities, including inhibition of cancerous cell growth and N-glycosylation. It has been used as a glycolysis inhibitor and as a potential energy restriction mimetic agent, inhibiting pathogen-associated molecular patterns. Radioisotope derivatives of 2-DG have applications as tracers. Recently, 2-DG has been used as an anti-COVID-19 drug to lower the need for supplemental oxygen. In the present review, various pharmaceutical properties of 2-DG are discussed.

PMID:36911357 | PMC:PMC9998157 | DOI:10.1155/2023/9993386