Acquired factor VII inhibitor associated with primary central nervous system Lymphoma: A case report

EJHaem. 2022 Jun 7;3(3):1000-1002. doi: 10.1002/jha2.482. eCollection 2022 Aug.


Paraneoplastic coagulopathies are uncommon in patients with lymphoma. We report the first case of an acquired coagulopathy in a patient with isolated primary central nervous system lymphoma (PCNSL) demonstrating large-cell histology. In our patient, a paraneoplastic factor VII inhibitor significantly delayed a diagnostic lumbar puncture despite fresh frozen plasma and inactivated prothrombin complex concentrate. While her coagulopathy was effectively overcome with recombinant activated factor VIIa and subsequently with lymphoma-directed therapy, her delayed diagnosis likely contributed to a poor outcome. Our case highlights the importance of rapidly identifying and correcting paraneoplastic coagulopathies when PCNSL is suspected.

PMID:36051043 | PMC:PMC9421997 | DOI:10.1002/jha2.482


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