Carbon dots nanozyme for anti-inflammatory therapy via scavenging intracellular reactive oxygen species

Front Bioeng Biotechnol. 2022 Aug 15;10:943399. doi: 10.3389/fbioe.2022.943399. eCollection 2022.

ABSTRACT

Developing an efficient antioxidant for anti-inflammatory therapy via scavenging reactive oxygen species (ROS) remains a great challenge owing to the insufficient activity and stability of traditional antioxidants. Herein, we explored and simply synthesized a biocompatible carbon dots (CDs) nanozyme with excellent scavenging activity of ROS for anti-inflammatory therapy. As expected, CDs nanozyme effectively eliminate many kinds of free radicals including •OH, O2•- , and ABTS+•. Benefiting from multienzyme activities against ROS, CDs nanozyme can decrease the levels of pro-inflammatory cytokines, resulting in good anti-inflammatory effect. Taken together, this study not only sheds light on design of bioactive antioxidants but also broadens the biomedical application of CDs in the treatment of inflammation.

PMID:36046669 | PMC:PMC9420844 | DOI:10.3389/fbioe.2022.943399

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