Catalytic asymmetric Friedel-Crafts alkylation of unprotected indoles with nitroalkenes using a novel chiral Yb(OTf)3-pybox complex

Sci Rep. 2023 Sep 7;13(1):14736. doi: 10.1038/s41598-023-41921-9.


Chiral chloro-indeno pybox has served as a new ligand for the Yb(OTf)3-catalyzed asymmetric Friedel-Crafts alkylation reaction of indoles with nitroalkenes. The tunable nature of pybox ligands enables the rational design of catalysts for optimal performance in terms of both activity and stereoselectivity in a Friedel-Crafts-type reaction. Good to excellent yields and enantioselectivities were obtained for a relatively wide range of substrates, including sterically hindered compounds, under optimized reaction conditions.

PMID:37679477 | PMC:PMC10484919 | DOI:10.1038/s41598-023-41921-9


Related Posts

Leave a Reply

Your email address will not be published. Required fields are marked *