Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment

Int J Nanomedicine. 2021 Dec 16;16:8141-8158. doi: 10.2147/IJN.S332385. eCollection 2021.

ABSTRACT

Chitosan has been investigated in several biological fields, including drug and gene delivery, tissue engineering antiviral and immunological adjuvant methods. It’s a cationic copolymer of N-acetyl glucosamine and D-glucosamine with different molecular chain lengths, compositions, and sequences than N-acetyl glucosamine and D-glucosamine. It is biocompatible and cyto-compatible, as well as recyclable and bioresorbable. As effective drug delivery methods, chitosan nanoparticles are shaped into several pathways. The purpose of this article is to provide an overview of its antiviral application as a nanocarrier for antiviral medications, highlighting the benefits, limitations, and downsides. In this review, we will report the most recent COVID-19 vaccination advances. It will also be discussed what the future holds for chitosan nanoparticles in the treatment of coronaviruses.

PMID:34949922 | PMC:PMC8689047 | DOI:10.2147/IJN.S332385

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