Due to their efficiency and accessibility, benzodiazepines are widely manufactured and consumed and as a result, they can be found in almost all wastewaters. Among the materials that were used for the removal of drug contaminants from wastewater, metal-organic frameworks (MOFs) demonstrated unique properties. In this regard, a composite of carboxymethylated cellulose (CMC) and MIL-100(Fe) was prepared via a sonochemical method and used for the removal of lorazepam from wastewater in various conditions. A maximum capacity of 811 mg g-1 was achieved which is considered a great improvement compared to bare MIL-100(Fe) (150 mg g-1) and other previously reported adsorbents. It is noteworthy that the efficiency of the adsorbent did not reduce in the second and third cycle of adsorption/desorption. Moreover, the effect of pH, dose of adsorbent, isotherms and the kinetics of this process were studied using UV-vis and HPLC analyses and the adsorbents were fully characterized with PXRD, TGA, BET, SEM, ZP and FT-IR techniques. Our findings demonstrate that this composite is clearly a green, recyclable and efficient adsorbent for the removal of lorazepam and opens our way to further potential applications in the removal of other active pharmaceutical ingredients.