Facile and innovative catalytic protocol for intramolecular Friedel-Crafts cyclization of Morita-Baylis-Hillman adducts: Synergistic combination of chiral (salen)chromium(III)/BF3·OEt2 catalysis

Beilstein J Org Chem. 2021 Aug 26;17:2186-2193. doi: 10.3762/bjoc.17.140. eCollection 2021.


The chiral (salen)Cr(III)/BF3·OEt2 catalytic combination was found to be an effective catalyst for intramolecular Friedel-Crafts cyclization of electron-deficient Morita-Baylis-Hillman adducts. In presence of mild reaction conditions the chiral (salen)Cr(III)/BF3·OEt2 complex affords 2-substituted-1H-indenes from unique substrates of Morita-Baylis-Hillman adducts via an easy operating practical procedure.

PMID:34497671 | PMC:PMC8404216 | DOI:10.3762/bjoc.17.140


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