Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)

Beilstein J Org Chem. 2023 Feb 23;19:212-216. doi: 10.3762/bjoc.19.20. eCollection 2023.

ABSTRACT

An iron(III) chloride hexahydrate-catalyzed Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates different electron-rich substrates under ambient atmosphere and allows for a multigram scale.

PMID:36865025 | PMC:PMC9972882 | DOI:10.3762/bjoc.19.20

Share:

Related Posts

Leave a Reply

Your email address will not be published. Required fields are marked *

Generated by Feedzy