Graphene-Based Scaffolds: Fundamentals and Applications for Cardiovascular Tissue Engineering

Front Bioeng Biotechnol. 2021 Dec 7;9:797340. doi: 10.3389/fbioe.2021.797340. eCollection 2021.

ABSTRACT

Cardiac tissue engineering requires materials that can faithfully recapitulate and support the native in vivo microenvironment while providing a seamless bioelectronic interface. Current limitations of cell scaffolds include the lack of electrical conductivity and suboptimal mechanical properties. Here we discuss how the incorporation of graphene into cellular scaffolds, either alone or in combination with other materials, can affect morphology, function, and maturation of cardiac cells. We conclude that graphene-based scaffolds hold great promise for cardiac tissue engineering.

PMID:34950649 | PMC:PMC8688816 | DOI:10.3389/fbioe.2021.797340

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