Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance

RSC Adv. 2023 Apr 11;13(17):11291-11295. doi: 10.1039/d3ra02031b. eCollection 2023 Apr 11.


Here we present an iridium catalysed C2-selective methylation of indoles using methyltrifluoroborate as a source of methyl group. The iridium catalyst selectively discriminates the indole C2 and C4 C-H bonds by coordination with a pivaloyl directing group.

PMID:37057266 | PMC:PMC10088075 | DOI:10.1039/d3ra02031b


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