New color-coded test quickly reveals whether medical nanoparticles have successfully delivered their payload

Johns Hopkins Medicine researchers have developed a color-coded test that quickly signals whether newly developed nanoparticles—ultra small compartments designed to ferry medicines, vaccines and other therapies—deliver their cargo into target cells. Historically, nanoparticles have a very low delivery rate to the cytosol, the inside compartment of cells, releasing only about 1%–2% of their contents. The new testing tool, engineered specifically to test nanoparticles, could advance the search for next-generation biological medicines. The technology builds upon nanoparticles currently used against cancer and eye disease, and in vaccines for viruses including SARS-CoV-2, the virus that causes COVID-19.

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