Novel fluorescence imaging assay gives new insight to develop biomimetic nanoparticles for targeted cancer therapy

Cell membrane coated biomimetic nanoparticles (NPs) have been widely studied in nanomedicine because of their unique properties such as immune escaping, long blood circulation, specific molecular recognition and efficient cancer targeting, indicating a great potential in targeted cancer therapy. However, the integrity of the cell membrane coating on NPs, a key metrics related to the quality of these biomimetic-systems and to the resulting biomedical function, has remained largely unexplored. In the present study, the researchers developed a fluorescence quenching assay to probe the integrity of the cell membrane coating.


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