Novel Strategy for Gallium-Substituted Hydroxyapatite/Pergularia daemia Fiber Extract/Poly(N-vinylcarbazole) Biocomposite Coating on Titanium for Biomedical Applications

ACS Omega. 2021 Aug 24;6(35):22537-22550. doi: 10.1021/acsomega.1c02186. eCollection 2021 Sep 7.


The current work mainly focuses on the innovative nature of nano-gallium-substituted hydroxyapatite (nGa-HAp)/Pergularia daemia fiber extract (PDFE)/poly(N-vinylcarbazole) (PVK) biocomposite coating on titanium (Ti) metal in an eco-friendly and low-cost way through electrophoretic deposition for metallic implant applications. Detailed analysis of this nGa-HAp/PDFE/PVK biocomposite coating revealed many encouraging functional properties like structure and uniformity of the coating. Furthermore, gallium and fruit extract of PDFE-incorporated biocomposite enhance the in vitro antimicrobial, cell viability, and bioactivity studies. In addition, the mechanical and anticorrosion tests of the biocomposite material proved improved adhesion, hardness, and corrosion resistance properties, which were found to be attributed to the presence of PDFE and PVK. Also, the swelling and degradation behaviors of the as-developed material were evaluated in simulated body fluids (SBF) solution. The results revealed that the as-developed composite exhibited superior swelling and lower degradation properties, which evidences the stability of composite in the SBF solution. Overall, the results of the present study indicate that these nGa-HAp/PDFE/PVK biocomposite materials with improved mechanical, corrosion resistance, antibacterial, cell viability, and bioactivity properties appear as promising materials for biomedical applications.

PMID:34514226 | PMC:PMC8427647 | DOI:10.1021/acsomega.1c02186


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