One-Pot Multicomponent Coupling Reaction of Catechols, Benzyl Alcohols/Benzyl Methyl Ethers, and Ammonium Acetate toward Synthesis of Benzoxazoles

ACS Omega. 2021 Aug 18;6(34):22395-22399. doi: 10.1021/acsomega.1c03207. eCollection 2021 Aug 31.

ABSTRACT

The multicomponent coupling reaction of catechol, ammonium acetate, and benzyl alcohol/benzyl methyl ether in the presence of a Fe(III) catalyst precursor afforded benzoxazole derivatives in good to excellent yields. The notable features of this protocol are abundant availability of the catalyst system, large-scale synthesis, high diversity, and high yields of products.

PMID:34497928 | PMC:PMC8412954 | DOI:10.1021/acsomega.1c03207

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