Photoinduced Trifluoromethylation with CF3Br as a Trifluoromethyl Source: Synthesis of α-CF3-Substituted Ketones

ACS Omega. 2022 Apr 12;7(16):14357-14362. doi: 10.1021/acsomega.2c01241. eCollection 2022 Apr 26.


An efficient and novel photoinduced trifluoromethylation employing CF3Br as a trifluoromethyl source is described. With commercially accessible fac-Ir(III)(ppy)3 as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF3Br occurs successfully. This method provides various α-CF3-substituted ketones with a broad substrate scope in good yields under mild reaction conditions.

PMID:35573213 | PMC:PMC9089747 | DOI:10.1021/acsomega.2c01241


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