Research Progress Based on Regulation of Tumor Microenvironment Redox and Drug-Loaded Metal-Organic Frameworks

Oxid Med Cell Longev. 2022 Jul 22;2022:7302883. doi: 10.1155/2022/7302883. eCollection 2022.

ABSTRACT

The process of tumor growth and deterioration is accompanied by increased oxygen free radicals, high glutathione concentration, hypoxia, and poor drug targeting during treatment, limiting the treatment of tumors. Metal-organic framework (MOF) preparations are continuously being developed and applied in tumor therapy. In this paper, the design and application of reactive oxygen species (ROS) and redox drug-loaded MOF preparations are reviewed. Moreover, the research challenges and application prospects of MOFs in tumor therapy are also discussed.

PMID:35910842 | PMC:PMC9337949 | DOI:10.1155/2022/7302883

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