Simultaneously enhancing the photocatalytic and photothermal effect of NH2-MIL-125-GO-Pt ternary heterojunction for rapid therapy of bacteria-infected wounds

Bioact Mater. 2022 Mar 29;18:421-432. doi: 10.1016/j.bioactmat.2022.03.035. eCollection 2022 Dec.


Infections caused by bacteria threaten human health, so how to effectively kill bacteria is an urgent problem. We therefore synthesized a NH2-MIL-125-GO-Pt ternary composite heterojunction with graphene oxide (GO) and platinum (Pt) nanoparticles co-doped with metal-organic framework (NH2-MIL-125) for use in photocatalytic and photothermal synergistic disinfection under white light irradiation. Due to the good conductivity of GO and the Schottky junction between Pt and MOF, the doping of GO and Pt will effectively separate and transfer the photogenerated electron-hole pairs generated by NH2-MIL-125, thereby effectively improving the photocatalytic efficiency of NH2-MIL-125. Meanwhile, NH2-MIL-125-GO-Pt has good photothermal effect under white light irradiation. Therefore, the NH2-MIL-125-GO-Pt composite can be used for effective sterilization. The antibacterial efficiency of NH2-MIL-125-GO-Pt against Staphylococcus aureus and Escherichia coli were as high as 99.94% and 99.12%, respectively, within 20 min of white light irradiation. In vivo experiments showed that NH2-MIL-125-GO-Pt could effectively kill bacteria and promote wound healing. This work brings new insights into the use of NH2-MIL-125-based photocatalyst materials for rapid disinfection of environments with pathogenic microorganisms.

PMID:35415303 | PMC:PMC8968451 | DOI:10.1016/j.bioactmat.2022.03.035


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