Single-step green synthesis of gold conjugated polyphenol nanoparticle using extracts of Saudi’s myrrh: Their characterization, molecular docking and essential biological applications

Saudi Pharm J. 2022 Sep;30(9):1215-1242. doi: 10.1016/j.jsps.2022.06.028. Epub 2022 Jul 3.


The progress in the innovative nanocrystal synthesis process by using environmentally benign and low-priced nontoxic chemicals, solvents, and renewable sources remains a challenging task for researchers worldwide. The majority of the existing synthesis techniques engage in the potentially dangerous, for either human health or the environment. Current investigation has been centered on green synthesis processes to create novel nanomaterials, which are eco-friendly as well as safer for sustainable marketable feasibility. The current work provides the green synthesis method for gold nanoparticle (GNPs) synthesis using Commiphora myrrh (C.myrrh) extract. This simple method includes 6 ml of HAuCl4·3H2O treated with 4 ml C.myrrh extract having pH 4.5 after 80 min at 25 °C temperature. In this novel method, green synthesized GNPs characterized by UV-Vis, X_ray diffraction spectroscopy (XRD), zeta potential, fourier transform infrared (FT_IR), high_resolution transmission electron microscopy (HR_TEM), energy dispersive X_ray spectroscopy (EDXA), and dynamic light scattering (DLS). During the development successful antioxidant assay, the DPPH assay was applied. The cell toxicity of green synthesized GNPs was evaluated following an MTT assay against HCT-116 (colon cancer) and MCF-7 (breast cancer). Besides molecular docking in the δ-elemene for inhibitor to VEGFR-2 domain revealed more negative docking score (-3.976) which is an excellent binding affinity to the C.myrrh@GNP. The synthesized GNPs showed antidiabetic, antibiotic, and antibacterial properties and anti_inflammatory inhibition against inhibiting COX-1, and COX-2 enzymes. In addition, molecular docking by Lindestrene (-3.806) and Furanoeudesma-1,3-dien (-3.912) against COX1 and COX2 respectively showed strong binding affinity. The molecular docking study evidenced the anti-inflammatory and cell toxicity study.

PMID:36249941 | PMC:PMC9562988 | DOI:10.1016/j.jsps.2022.06.028


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