Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures

Beilstein J Org Chem. 2022 Mar 22;18:331-336. doi: 10.3762/bjoc.18.37. eCollection 2022.


A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid-N,N-dimethylurea mixtures is reported. This solvent-free method is very general and provides easy access to 5-unsubstituted dihydropyrimidinone-4-carboxylate derivatives in good yields.

PMID:35387381 | PMC:PMC8965339 | DOI:10.3762/bjoc.18.37


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