Synthesis of a Zirconium Complex of an N,O-type ptert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions

ACS Omega. 2022 Aug 4;7(32):28471-28480. doi: 10.1021/acsomega.2c03187. eCollection 2022 Aug 16.


The synthesis and characterization of a new octahedral Zr(IV) complex of oxygen-depleted N,O-type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffraction and NMR studies. The Zr metal lies at 2.091 Å from the plane of the calixarene ring. This complex has been utilized as an efficient catalyst for the synthesis of Biginelli adducts, bis(indolyl)methanes, and coumarins. This complex (Cl2Zr-calixarene) showed superior activity for these multicomponent reactions in comparison to the corresponding Ti(IV) and Zn(II) analogues. Ferrocene-appended bis(indolyl)methane, prepared using this catalyst, was also evaluated for its anticancer activity against the A-172 cell line.

PMID:35990458 | PMC:PMC9386809 | DOI:10.1021/acsomega.2c03187


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