Synthesis of bis-spiro piperidines using nano γ-alumina supported Sb(v) under ultrasonic irradiation at room temperature conditions

RSC Adv. 2023 May 23;13(23):15667-15673. doi: 10.1039/d3ra00448a. eCollection 2023 May 22.


Group VA metalloid ion Lewis acids, Sb(v) was identified as a highly potent catalyst for the one-pot three-component synthesis of bis-spiro piperidine derivatives. The reaction was performed using amines, formaldehyde, and dimedone under ultrasonic irradiation at room temperature. The strong acidic property of the nano γ-alumina supported antimony(v) chloride plays a key role in accelerating the rate of the reaction and initiates the reaction smoothly. The heterogeneous nanocatalyst was fully characterized by FT-IR spectroscopy, XRD, EDS, TGA, FESEM, TEM, and BET techniques. Also, the structures of the prepared compounds were characterized by 1H NMR and FT-IR spectroscopies.

PMID:37228678 | PMC:PMC10204700 | DOI:10.1039/d3ra00448a


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