Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development

Signal Transduct Target Ther. 2023 Mar 11;8(1):112. doi: 10.1038/s41392-023-01375-x.


The fast-developing synthetic biology (SB) has provided many genetic tools to reprogram and engineer cells for improved performance, novel functions, and diverse applications. Such cell engineering resources can play a critical role in the research and development of novel therapeutics. However, there are certain limitations and challenges in applying genetically engineered cells in clinical practice. This literature review updates the recent advances in biomedical applications, including diagnosis, treatment, and drug development, of SB-inspired cell engineering. It describes technologies and relevant examples in a clinical and experimental setup that may significantly impact the biomedicine field. At last, this review concludes the results with future directions to optimize the performances of synthetic gene circuits to regulate the therapeutic activities of cell-based tools in specific diseases.

PMID:36906608 | PMC:PMC10007681 | DOI:10.1038/s41392-023-01375-x


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