Tetratricopeptide repeat domain 9A knockout induces social anxiety and impairs offense behaviors in female mice

Iran J Basic Med Sci. 2022 Jun;25(6):698-703. doi: 10.22038/IJBMS.2022.63044.13932.

ABSTRACT

OBJECTIVES: The involvement of tetratricopeptide repeat domain 9A (TTC9A) in anxiety-like behaviors through estrogen action has been reported in female mice, this study further investigated its effects on social anxiety and aggressive behaviors.

MATERIALS AND SMETHODS: Using female Ttc9a knockout (Ttc9a-/-) mice, the role of TTC9A in anxiety was investigated in non-social and social environments through home-cage emergence and social interaction tests, respectively, whereas aggressive behaviors were examined under the female intruder test.

RESULTS: We observed significant social behavioral deficits with pronounced social and non-social anxiogenic phenotypes in female Ttc9a-/- mice. When tested for aggressive-like behaviors, we found a reduction in offense in Ttc9a-/- animals, suggesting that TTC9A deficiency impairs the offense responses in female mice.

CONCLUSION: Future study investigating mechanisms underlying the social anxiety-like behavioral changes in Ttc9a-/- mice may promote the understanding of social and anxiety disorders.

PMID:35949301 | PMC:PMC9320210 | DOI:10.22038/IJBMS.2022.63044.13932

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