Front Neurosci. 2023 May 9;17:1178606. doi: 10.3389/fnins.2023.1178606. eCollection 2023.
Repetitive electrical nerve stimulation can induce a long-lasting perturbation of the axon’s membrane potential, resulting in unstable stimulus-response relationships. Despite being observed in electrophysiology, the precise mechanism underlying electrical stimulation-dependent (ES-dependent) instability is still an open question. This study proposes a model to reveal a facet of this problem: how threshold fluctuation affects electrical nerve stimulations. This study proposes a new method based on a Circuit-Probability theory (C-P theory) to reveal the interlinkages between the subthreshold oscillation induced by neurons’ resonance and ES-dependent instability of neural response. Supported by in-vivo studies, this new model predicts several key characteristics of ES-dependent instability and proposes a stimulation method to minimize the instability. This model provides a powerful tool to improve our understanding of the interaction between the external electric field and the complexity of the biophysical characteristics of axons.
PMID:37229430 | PMC:PMC10203711 | DOI:10.3389/fnins.2023.1178606