The effects of chitosan supplementation on anthropometric indicators of obesity, lipid and glycemic profiles, and appetite-regulated hormones in adolescents with overweight or obesity: a randomized, double-blind clinical trial

BMC Pediatr. 2022 Sep 5;22(1):527. doi: 10.1186/s12887-022-03590-x.

ABSTRACT

BACKGROUND: Chitosan is one of dietary fiber that has received great attention in improving obesity-related markers, but little is known on its effects on adolescents.

OBJECTIVES: To analyze the effects of chitosan supplementation on obesity-related cardiometabolic markers and appetite-related hormones in adolescents with overweight or obesity.

METHODS AND ANALYSIS: A randomized clinical trial was performed on 64 adolescents with overweight and obesity, who were randomly allocated to receive chitosan supplementation (n = 32) or placebo as control (n = 32) for 12 weeks. Anthropometric measures, lipid and glycemic profiles, and appetite-related hormones were examined.

RESULTS: Sixty-one participants completed study (chitosan = 31, placebo = 30). Chitosan supplementation significantly improved anthropometric indicators of obesity (body weight: – 3.58 ± 2.17 kg, waist circumference: – 5.00 ± 3.11 cm, and body mass index: – 1.61 ± 0.99 kg/m2 and – 0.28 ± 0.19 Z-score), lipid (triglycerides: – 5.67 ± 9.24, total cholesterol: – 14.12 ± 13.34, LDL-C: – 7.18 ± 10.16, and HDL-C: 1.83 ± 4.64 mg/dL) and glycemic markers (insulin: – 5.51 ± 7.52 μIU/mL, fasting blood glucose: – 5.77 ± 6.93 mg/dL, and homeostasis model assessment of insulin resistance: – 0.24 ± 0.44), and appetite-related hormones (adiponectin: 1.69 ± 2.13 ng/dL, leptin – 19.40 ± 16.89, and neuropeptide Y: – 41.96 ± 79.34 ng/dL). When compared with the placebo group, chitosan supplementation had greater improvement in body weight, body mass index (kg/m2 and Z-score), waist circumference, as well as insulin, adiponectin, and leptin levels. Differences were significant according to P-value < 0.05.

CONCLUSION: Chitosan supplementation can improve cardiometabolic parameters (anthropometric indicators of obesity and lipid and glycemic markers) and appetite-related hormones (adiponectin, leptin, and NPY) in adolescents with overweight or obesity.

PMID:36064382 | PMC:PMC9442917 | DOI:10.1186/s12887-022-03590-x

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