Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain

Nat Commun. 2022 Jul 15;13(1):4086. doi: 10.1038/s41467-022-31537-4.

ABSTRACT

Kv3 channels enable neurons to fire at very high frequencies (>100 Hz) which is fundamental to brain development and our ability to make sense of the world at large. Cryo-EM and structure-function studies by Chi et al. now uncover Kv3 channel gating mechanisms and support new precision medicine approaches for CNS diseases.

PMID:35840565 | PMC:PMC9287389 | DOI:10.1038/s41467-022-31537-4

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