Tracking the nitric oxide signaling pathway

Both nitric oxide (NO) and hydrogen sulfide (H2S) act as gaseous signaling molecules with similar physiological effects. Many of the critical questions about the interplay between these two gasotransmitters hinge on their chemical reactivity and the fleeting existence of HSNO, a key product of the reaction between them. A team of researchers has been able to stabilize, isolate, and characterize two of the species tied to these signaling pathways through binding to a zinc complex, as reported in the journal, Angewandte Chemie.

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