Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C-H Functionalization Mediated by tert-Butyl Hydroperoxide

ACS Omega. 2021 Sep 28;6(40):25940-25949. doi: 10.1021/acsomega.1c02645. eCollection 2021 Oct 12.

ABSTRACT

A novel metal catalyst-free and environmentally friendly method for the regioselective iodination of imidazo[1,2-α]pyridines at their C3 position is disclosed, which has a wide substrate scope and could be sustainable. This reaction proceeds through ultrasound acceleration in the presence of a green alcohol solvent. Compared with a conventional heating system, the reaction efficiency and the rate are significantly improved and the iodine atom economy is maximized using ultrasound techniques.

PMID:34660956 | PMC:PMC8515396 | DOI:10.1021/acsomega.1c02645

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