Versatile Synthetic Platform for 1,2,3-Triazole Chemistry

ACS Omega. 2022 Oct 10;7(42):36945-36987. doi: 10.1021/acsomega.2c04883. eCollection 2022 Oct 25.


1,2,3-Triazole scaffolds are not obtained in nature, but they are still intensely investigated by synthetic chemists in various fields due to their excellent properties and green synthetic routes. This review will provide a library of all synthetic routes used in the past 21 years to synthesize 1,2,3-triazoles and their derivatives using various metal catalysts (such as Cu, Ni, Ru, Ir, Rh, Pd, Au, Ag, Zn, and Sm), organocatalysts, metal-free as well as solvent- and catalyst-free neat syntheses, along with their mechanistic cycles, recyclability studies, solvent systems, and reaction condition effects on regioselectivity. Constant developments indicate that 1,2,3-triazoles will help lead to future organic synthesis and are useful for creating molecular libraries of various functionalized 1,2,3-triazoles.

PMID:36312377 | PMC:PMC9608397 | DOI:10.1021/acsomega.2c04883


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