Zinc Chloride-Catalyzed Synthesis of Carbamates: An Application for the Synthesis of the Anti-Alzheimer’s Drug Rivastigmine

ACS Omega. 2022 Sep 26;7(40):36017-36027. doi: 10.1021/acsomega.2c05350. eCollection 2022 Oct 11.

ABSTRACT

Herein, we report a synthetic protocol for the synthesis of carbamates by employing zinc chloride as a catalyst from carbamoyl chlorides and aromatic/aliphatic alcohols. The developed protocol successfully utilizes the gram-scale synthesis of the FDA-approved rivastigmine drug and its derivative. The utility of zinc chloride over other catalysts such as zinc dust and zinc acetate exhibits a 49-87% yield of carbamates.

PMID:36249350 | PMC:PMC9557893 | DOI:10.1021/acsomega.2c05350

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